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- Sela Ward was offered the role of Megan Donner but turned it down.
- The Miami-Dade Police Department's crime lab really is called Crime Scene Investigations
- Because of the October 2002 DC-area sniper killings, CBS considered delaying the broadcast of episode #1.9, "Kill Zone",
in which Horatio pursues a sniper. However, when two suspects were arrested and charged with the sniper slayings at the end
of October, the network reconsidered, and chose to air the episode during the November 2002 sweeps as originally planned.
(The episode was not inspired by the DC-area sniper slayings, since the script was written before the attacks took place.)
- Episode #1.22, "Tinder Box", was blacked out in Rhode Island during its initial broadcast due to its near-direct similarity
to The Station nightclub fire. (It was blacked out again in Rhode Island when the episode was repeated in the summer of 2003.)
- While all the fly-over shots, skylines and cityscapes really are of Miami, Florida, any beach scenes during the series
were filmed at Manhattan Beach, a suburb of Los Angeles.
- "CSI: Crime Scene Investigation" (2000) star William L. Petersen was offered the chance to produce this show, but declined.
- Believing that CSI copycat shows were inevitable, CSI producers and CBS agreed to create this spin-off series in the hope
of being the first to copy the original CSI series.
- In episode #1.13, "Bunk" (broadcast 13 January 2003), it is revealed that Horatio Caine's younger brother, Raymond Caine,
was killed in 2001 (according to his tombstone he was born 1968).
- Jonathan Togo first appeared on the show in episode #3.3, "Under the Influence", but he did not become a regular until
episode #3.6, "Hell Night".
- The design of the autopsy theater was based on a misremembering of a set from The Andromeda Strain (1971).
- In episode #1.8, "Slaughterhouse", Eric Delko revels his "real" last name is revealed as "Delektorsky", from his Russian
father. (His mother is Cuban.)
- Horatio was named after the poet Horatio Alger.
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